Choosing an audio interface that works seamlessly with Cubase can elevate recording, mixing, and monitoring. The following five models balance reliable drivers, high-quality preamps, and Cubase-friendly features, giving American creators solid options for guitar, voice, podcasts, and music production. Each offers varying I/O, latency performance, and bundled software to suit different home-studio setups.
| Product | Brand | Key Feature |
|---|---|---|
| Steinberg UR22C | Steinberg | 32-bit/192 kHz, USB-C, D-PRE mic preamps |
| Steinberg UR44C | Steinberg | 6 x 4 I/O, 32-bit/192 kHz, USB-C, D-PRE preamps |
| Steinberg IXO12 | Steinberg | 2 x 2 I/O, USB 2.0, Cubase AI included |
| Focusrite Scarlett Solo (3rd Gen) | Focusrite | High-headroom preamps, Air mode, 24-bit/192 kHz |
| MAONO PS22 Lite | MAONO | 24-bit/192 kHz, XLR input, versatile for recording and streaming |
Steinberg UR22C 2×2 USB 3.0 Interface

The Steinberg UR22C 2×2 USB 3.0 interface delivers 32-bit/192 kHz audio resolution and class-leading D-PRE mic preamps for capturing subtle nuances in vocals or instruments. It uses USB-C connectivity for fast and reliable links to Mac, PC, and iOS devices, supporting Cubase workflows and third-party DAWs. This model is well-suited for compact studios seeking high fidelity, versatile I/O, and dependable Cubase integration.
Steinberg UR44C 6×4 USB 3.0 Interface

The UR44C expands the feature set with 6-in/4-out capability and USB-C connectivity, offering Studio-grade converters up to 32-bit/192 kHz and Class-A D-PRE preamps. Built for musicians and podcasters, it supports Cubase AI and provides robust routing options for complex projects while maintaining low latency and reliable performance across multiple inputs and outputs.
Steinberg IXO12 White

The IXO12 provides a compact 2×2 USB audio solution with 24-bit/192 kHz resolution and a built-in combination input with phantom power for versatile recording. It includes Cubase AI and Cubasis LE, making it a convenient choice for Cubase users who need a portable interface with reliable performance and straightforward control on the go or in a small studio setup.
Focusrite Scarlett Solo (3rd Gen)

The Scarlett Solo 3rd Gen offers pro-level preamps, an Air mode for added brightness on acoustic instruments, and high headroom for clean recordings. It features two inputs—one instrument and one XLR mic—facilitating quick, high-quality guitar and vocal takes. Its 24-bit/192 kHz converters ensure faithful capture and optional Nebula-like clarity during mixing in Cubase.
MAONO PS22 Lite USB Audio Interface

The MAONO PS22 Lite provides 24-bit/192 kHz recording with a dynamic range suitable for podcasting, streaming, and home-studio use. It includes a dedicated XLR input with phantom power for condenser mics and a Hi-Z instrument input for guitar or bass. A practical solution for budget-conscious Cubase users seeking clear, realistic recordings and easy setup.
Buying Guide
Key purchase considerations for Cubase users include input/output needs, preamp quality, and latency performance. If you plan to record multiple instruments or tracks simultaneously, prioritize interfaces with more analog I/O and robust driver support. For solo artists or podcasters, a compact model with high-quality preamps and low-latency monitoring can be sufficient. Consider bundled software and Cubase compatibility, as some interfaces include Cubase AI or Cubasis LE, which can provide a quick start into project creation. Connectivity options such as USB-C or USB-C to USB-C can also impact compatibility with modern laptops and desktops. Finally, assess build quality and portability if you travel or work in different environments.
Comparisons by scenario:
– For Cubase-centric studios: Look for interfaces with Cubase AI integration, low-latency monitoring, and reliable drivers (e.g., Steinberg UR series).
– For singers and podcasters: Focus on clean preamps, low noise floors, and ability to drive dynamic or condenser mics with phantom power.
– For guitar-centric setups: Consider instrument inputs with impedance matching and optional “Air” or brightening modes to preserve guitar clarity.
– For budget-conscious setups: MAONO or similar brands can deliver solid 24-bit/192 kHz performance at a lower price point, though you may trade some features or durability.
– For portability: Compact 2×2 or 2×4 models with USB-C connectivity suit mobile recording and quick podcasting workflows.